: Introduction: Cantilevered anterior fixed partial dentures (FPDs) are a viable treatment option for patients with esthetic concerns, particularly when implants are not suitable due to medical conditions or financial constraints. These prostheses provide a conservative, minimally invasive solution to restore both function and appearance. Objective: This case report aims to demonstrate the use of a cantilevered anterior FPD for esthetic rehabilitation in a medically compromised patient undergoing radiotherapy for breast cancer, with a focus on achieving an optimal esthetic result while considering the patient's medical and financial limitations. Patient and Methods: A 42-year-old female patient presented with severe mobility of tooth 12 and a 1mm midline diastema. After initial periodontal therapy (scaling and root planing), the treatment plan was established. The adjacent teeth (11 and 21) were prepared for full coverage crowns, and tooth 12 was extracted atraumatically. An immediate provisional cantilever bridge was placed, followed by final impressions for the fabrication of a ceramo-ceramic cantilever bridge with tooth 22 in extension. Results: The final prosthesis successfully restored the patient's smile, providing immediate esthetic improvement and functional stability. The cantilevered bridge with tooth 22 in extension closed the midline diastema, with no complications observed during the healing phase. The patient expressed high satisfaction with the esthetic outcomes and functional restoration. Conclusion: This case highlights the effectiveness of cantilevered anterior FPDs as an esthetic and functional solution for patients with medical conditions that preclude implant therapy. The treatment was minimally invasive, cost-effective, and met the patient’s needs for a rapid, non-surgical approach. Cantilevered bridges offer a viable alternative for esthetic rehabilitation in medically compromised patients, though further research is needed to assess ...