The Coronavirus disease 2019 (COVID-19) has been a global outbreak and emergency declared by the WHO. Yet no conformed vaccine or drug that will end this pandemic crisis as it takes months if not years to develop as well as it is costly and the process to deliver the drug to the whole world is long while people are dying from the deadly virus. The hyper-oxidative stress that resulted from the pathogenesis of SARS-CoV-2 leads to detrimental consequences and multiple organ failures that leads to sudden death. As it’s evident from the free radical theory, the release of oxidative iron from hemoglobin overwhelms the natural detoxifying mechanisms leading to prolonged and persistent hypoxia. Antioxidants like N-Acetyl cysteine are suggested as a viable therapeutic approach for attenuating tissue damage induced by oxidative stress. An overreaction of the immune system will develop as a form of systemic inflammatory response, which is called a cytokine storm. Unlike free radical theory, cytokine storm theory may not always lead to multiorgan failures and death. This emphasizes the seriousness of free radical theory and the promising role of antioxidant use in SARS-COV-2 in infected critically ill patients. Therapeutic infusion of N-Acetyl cysteine will increase the levels of glutathione which counteracts the catastrophic action of free radicals by boosting cellular defense against oxidative stress.