Around 2 million individuals all over the globe are infected with the novel coronavirus 2019 that has emerged from Wuhan, China. It has rapid spreading rate by small droplets coming from sneezing or coughing of infected individual or asymptomatic carrier individual. The current management strategy is supportive; mainly hemodynamic and respiratory support. Fatalities are caused by severe pneumonia, sepsis, multi-organ failure, respiratory arrest and heart attack. Recent COVID-19 reports suggest a relation between hyper oxidative stress, caused by viral infection generally and heme dissociation particularly, and increased clinical deterioration of the patients. Patients suffers from cytokine storm and hyper-inflammatory status. In addition, they might be suffering from free heme accumulation and radical storm. Symptomatic and supportive treatments are needed at the same time side by side. ). There are a lot of research and clinical trial to find a treatment or vaccine for this pandemic and only some of them were applied in clinical practice. Adjuvant micronutrients support is expected to decrease the oxidative stress status in these patients especially critically ill. Micronutrients includes vitamins C, A, E and trace element selenium are known for their anti-inflammatory and anti-oxidant effect.Through this review article, we highlight potential effect of use of antioxidant-4 cocktail COVID-19 infected patients.