Introduction: Ionic disorders are an imbalance between the ions entering and leaving the body. We studied dysnatremia and dyskaliaemia in patients admitted in resuscitation department. Patients and Method: This is a retrospective, descriptive and analytical study of dysnatremias and dyskaliaemias in patients hospitalized in the resuscitation department Peace Hospital of Ziguinchor from January 1st, 2021 to December 31th, 2021. The objectives were to assess the prevalence of these ionic disorders in resuscitation, to clarify the epidemiological profile, to identify clinical and paraclinical signs, to evaluate management and to monitor the evolution of patients. Results: During the study period, the Peace Hospital resuscitation service recorded 287 hospitalizations, among which we identified 66 cases of ionic disorders (dysnatremias and dyskaliaemias) at admission. We found a frequency of 22.9% of hospitalized patients. The average age was 40.71 ± 23.83 years. Males were the most represented in 53%. The majority of patients, 62.1%, came from outside the city of Ziguinchor. Diabetes was the most common medical history in 50% of patients. Patients were from 53% of emergency department. Stroke was the most common cause in 16.7%. Dysnatremias were found in 57 patients, or 86.4%. Dyskaliaemias were found in 32 patients or 48.5%. Clinical signs were marked by the disorder of consciousness in 37.9%. Electrical signals were more marked by the flattened/negative T wave and ST depression in 60%. We reported a 53% mortality rate. Deaths occurred in 60% within 72 hours of hospitalization. Severe malaria and hyperkalemia were factors of poor prognosis. Conclusion: The ionic disorders, frequent in resuscitation, are of multifactorial origin. They are associated with significant morbidity and mortality and require early and accurate management.