The aim of this study was to assess cost-effectiveness of four improved and enriched infant flours. The study was carried out at the Supplementary Nutrition Unit (UNS) of the Notre Dame of Apostles Hospital (HNDA) at N’Djamena. The results of the study, which included 416 children, showed that moderately malnourished children on experimental flours with dried Moringa oleifera leaf powder took a maximum of three weeks to recover from malnutrition. The Pennisetum typhoïdes flour with Moringa gave the best results, with 96% of children recovering after an average duration of recovery of 17.5 days. Children on red sorghum flour from Bongor without Moringa (SRBSM) showed the highest daily weight gain in the study, at 8 g/kg-body weight per day. The same flour, SRB, with Moringa showed the highest hemoglobin gain of 13.5 g/dl. Children on maize flour without Moringa took the longest to recover in the study, an average of 32.7 days. To conclude, in in accordance with our results, from a cost-effectiveness point of view, flours of Pennisetum typhoïdes and red sorghum flours with Moringa leaf powder showed the best results of the study. They are likely to help improve health and reduce the prevalence of malnutrition, which is currently recurrent among a large proportion of Chadian children.