Anaesthetic manoeuvres like direct laryngoscopy, tracheal intubation, extubation, pneumoperitoneum and CO2 insufflations necessary in laparoscopic surgeries causes increase in plasma stress hormone which leads to increase in heart rate (HR), mean arterial blood pressure (MAP), systemic and pulmonary vascular resistance and decrease cardiac output. In this randomized open labeled observer blinded study, we compared effect of esmolol and dexmedetomidine to attenuate pressure response to laryngoscopy, intubation and pneumoperitoneum during laparoscopic surgery. Ninety patients belonging to ASA I and II were divided into three groups. Patients of group-D received dexmedetomidine (0.5 mcg/kg) IV as loading dose over 10min, followed by 0.4mcg/kg/hr till the end of pneumoperitoneum and patients of group-E received esmolol (0.5mg/kg) IV as loading dose over 5 min followed by 50mcg/kg/min till the end of pneumoperitoneum. Patients of group-C received same volume of normal saline. During laryngoscopy, intubation, pneumoperitoneum, at reversal and extubation HR, MAP, oxygen saturation and end tidal CO2 (EtCO2) were observed. Recovery in terms of time to respond to oral-commands, extubation and full orientation was noted along with any adverse effects. In control group, there was significant increase in HR and MAP during intubation, extubation and pneumoperitoneum. In dexmedetomidine group we observed better control of HR and MAP as compare to esmolol and control groups. In esmolol group, only HR was controlled at intubation, while during pneumoperitoneum HR and MAP both were near baseline values. Dexmedetomidine and esmolol both are effective to provide hemodynamic stability in laparoscopic surgery. But dexmedetomidine is more effective than esmolol with minimal incidence of bradycardia.