Introduction: Cutaneous leishmaniasis (CL) is the most common clinical manifestation of leishmaniasis, a neglected tropical disease (NTD). It is caused by Leishmania transmitted to humans by the bite of a small infested sandfly: the female sandfly. The objective of our study is to determine the epidemiological, clinical profile and the nature of the parasite responsible for LC in Zinder. Materials and Method: This is a cross-sectional descriptive study. Retrospective data was collected from patients registered at the laboratory level of the district hospital and the Kara-kara health center from January 2017 to May 2021. This study helped determine the frequency of CL in the Zinder region as well as the socio-demographic characteristics of the cases. The prospective collection carried out at the HNZ over a period of seven (7) months from June 01, 2021 to December 31, 2021, made it possible to determine the nature of the parasite responsible for CL in Zinder as well as the management practices. Discussion/Conclusion: This study is the first to identify in molecular biology the parasite responsible for CL in Niger. The parasitic species identified in circulation in the city of Zinder was L. major for all PCR positive cases. Metronidazole was the reference treatment; administered orally. The evolution was favorable with a cure rate of 66% and 44% of sight loss.