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A Clinical Study to Assess the Hypotensive Property of Dexmedetomidine and its Efficacy to Provide Oligemic Surgical Field in Middle Ear Surgery

DOI : https://doi.org/10.36349/EASJACC.2020.v02i01.004
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Middle ear surgery is a type of microsurgery which requires minimum extravasation of blood into the surgical field for a better vision during surgery and hence a better outcome of surgery. The objective of the present study was to use dexmedetomidine an alpha-2 agonist to provide hypotensive anesthesia to minimize blood spillage during the middle ear surgeries. In this study the sample size was 25 subjects for each group at an alpha error 0.05 and power 80%. With written, informed consent, 50 patients of ASA grade I and II, aged 18-58 years, weight 40-70 kgs, undergoing elective surgeries under general anaesthesia, were randomly allocated into two groups. Group-A received Dexmedetomidine 1mcg/kg loading dose over 10 mins after premedicatiom but before induction and a maintenance infusion of 0.4mcg/kg/hr which was stopped 20 mins before completion of surgery. Group-B received 10 ml normal saline as placebo. All the patients were observed intra operatively for vitals (HR, SBP, DBP, MAP, SPO2), suction requirement every 15 minutes and post operatively for Ramsay sedation score. It was observed that patients in group – A had significantly lower HR, SBP, DBP, MAP as compared to group – B. Both the groups were comparable for demographics, SPO2 , suctioning requirement during surgery and post operative sedation. Our study concluded that Dexmedetomidine is effective in providing hypotensive anesthesia and can be used to provide oligemic surgical field without post operative sedation.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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