EAS Publisher | Multiple Myeloma in a Young Patient Revealed by Lumbosciatica: A Case Report

Multiple Myeloma in a Young Patient Revealed by Lumbosciatica: A Case Report

DOI : https://doi.org/10.36344/ccijmb.2025.v07i01.001

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Multiple myeloma, a malignant hematologic disorder characterized by excessive monoclonal plasma cell proliferation in the bone marrow, is rare in individuals under 40, comprising less than 2% of cases. This report details a 27-year-old patient with left-sided lumbosciatica and clinical signs of lumbar and radicular syndrome at the S1 level. Imaging revealed multiple osteolytic lesions with perilesional sclerosis and abnormalities in the first sacral foramen. Biological findings included normochromic normocytic anemia, hypercalcemia, elevated sedimentation rate, monoclonal IgG Kappa, free Kappa light chains, hyperproteinemia, and hypoalbuminemia. A bone marrow biopsy confirmed 95% plasma cell infiltration. The patient underwent a VRD regimen and three cycles of D-VRD and is awaiting autologous stem cell transplantation. This case underscores the need to consider multiple myeloma in young patients, as failure to do so could delay critical diagnosis and treatment.

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