A field experiment was made to evaluate the effects of organic and inorganic fertilizers on the growth and yield of wheat and soil chemical properties. The study was conducted for two consecutive cropping seasons (2023-2024) on farmers’ fields in the Sinana district of Oromia National Regional State. Therefore, this study has attempted to evaluate the effect of the integrated use of vermicompost and inorganic fertilizer on bread wheat production and soil fertility improvement in the study area. Fertilizer source organic Sources of nutrients both included (vermicompost) and inorganic fertilizer (urea and NPS) were used in the integrated form. These treatments consist of: T1 = Control (no input) T2 = Recommend NP, T3 =25% RVC + 75% N + Rec P, T4 =100% RVC + rec P, T5 =50% RVC + 50% N + rec P and T6 =75% RVC + 25% N + Rec P. The experiment was a randomized complete block design with three replications. Soil sampling and agronomic data on wheat grain yield and yield components were collected. Accordingly, the highest mean grain yield (5403.67kgha-1) was recorded from the plot of T2 (Recommended rate from inorganic) flowed by (5186.00 kgha-1) was recorded from T3 (25% RVC + 75% N + Rec P) while the lowest grain yield (2637.67 kgha-1) was recorded from control plot. The partial budget analysis was performed for alternative uses of integrated organic and inorganic fertilizer applications for bread wheat production. The results showed that the application of integrated vermicompost with recommended rates of inorganic NP significantly increased the yield and yield components. It can be concluded that the application of integrated vermicompost and recommended rate of inorganic NP fertilizers (25 % Equivalent N from + 75 % N + Rec P is desirable) based on environmental sustainability for future productivity. This experiment has to be repeated over seasons and locations to make conclusive recommendations for the study area.