Introduction: The management of postoperative pain is a public health problem in our context. The aim of this work is to study the management of postoperative pain at Zinder National Hospital. Patients and method: This was a prospective cross-sectional study including patients operated on at Zinder National Hospital from June 1 to December 31, 2023 (6 months). Results: During the study period, 1349 patients underwent surgery, 250 of whom met our inclusion criteria, i.e. a frequency of 18.53%. The mean age of patients was 40.01±21.05 years, with extremes of 15-88 years. Males predominated in 75% of cases, with a sex ratio (M/F) of 3. General anesthesia (GA) was used in 60.4% of cases. In 54.8% of cases, the classification was ASA I. The most commonly used drug regimen for anesthesia was (fentanyl, Suxamethonium and ketamine) in 38.4% of cases. We selected and assessed our patients using the visual analog scale (VAS). Patients with no postoperative pain at H0, H6, H12, H 24 represented 69.2%; 42.8%; 36.8%; and 55.6% respectively. The most commonly used medications were Paracetamol, Tramadol and Néfopam. Nausea and/or vomiting occurred in 3.6% of cases. The outcome was favorable, with a 92.4% satisfaction rate. Conclusion: Postoperative pain management was multimodal and satisfactory with fewer side.