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Comparative Differential Dose of Topical Bupivacaine for Post-Operative Pain Management in Paediatric Ambulatory Tonsillectomy: A Prospective Randomized Study

DOI : https://doi.org/10.36349/easjacc.2019.v01i06.001
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Introduction: Tonsillectomy is one of the most commonly performed procedures in Otolaryngology. Nowadays tonsillectomy is carried out more as a day care surgery and this trend is increasing, Discharge from day case surgery may not be possible in some of the patients.The factors responsible for this include post-tonsillectomy pain, Bupivacaine when used topically for post tonsillectomy pain relief in children, has been shown to be safe with no complications. This study aims to determine effective dose of 0.5% bupivacaine and 0.25% Bupivacaine topically applied in reducing post tonsillectomy pain. Material and methods: This is a prospective randomized, double blind study of sixty patients ASA I and II patients aged between 5 to 12 years scheduled for ambulatory tonsillectomy. Anaesthesia was standardized for all patients fentanyl 1µ/kg was used as intra operative analgesia, patients were randomized into group A, who received 0.5% Bupivacaine and group B received 0.25% Bupivacaine both solutions were prepared and labeled by the research assistant who is in custody of the envelopes. After haemostasis was achieved, group A patients had both sides of their tonsillar fossae tightly packed for 5 minutes with a standard gauze of 10cm dimension folded twice to make it 2.5 by 2.5cm and fully soaked with 5ml of 0.5% bupivacaine. Group B patients received 5mls of 0.25% of bupivacaine soaked gauze was applied for 5 minutes as applied in group A. In both groups both the patients/parents or guardian and the researcher were blinded to the agent being used. Results: There was significant reduction in pain intensity among patients that received topical application of 0.5% bupivacaine 1.46(±1.17) & 2.80(±0.81) compare to those received 0.25% bupivacaine 3.16(±1.38) & 3.02(±1.62), time to first analgesic request (TFA) was longer in group A 8.84 (3.24) hours, when compared to group B which had a mean duration of 6.72(1.56) hours, with a p-value of 0.036. The cumulative dose of paracetamo

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Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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