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A Comparative Study of Hyperbaric Ropivacaine with Dexmedetomidine As a Lower Abdominal Surgeries- A Double Blind Randomized Trial

DOI : https://doi.org/10.36349/easjacc.2019.v01i06.003
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Background and Aims: To compare the efficacy and safety of intrathecal hyperbaric Ropivacaine without adjuvant and with adjuvant Dexmedetomidine for lower abdominal surgeries. Methods: This was a prospective, randomized, double-blind, comparative study conducted among the patients who were ASA grade I or II, age 18 to 60 years planned for lower abdomen surgeries under spinal anaesthesia. Patients were randomly allocated to two groups (30 in each): Ropivacaine Group (control group or R group): spinal anesthesia with 3ml of 0.6% hyperbaric Ropivacaine (18mg) + 0.5ml NS. Dexmedetomidine Group (R+D or D group): spinal anesthesia with 3ml of 0.6% hyperbaric Ropivacaine (18mg) + 0.5ml Dexmedetomidine (5 mcg). All patients scheduled for operation were given oral tablets ranitidine 150 mg and Alprazolam 0.25mg in the night before surgery. Results: There was no significant difference in the basic characteristics between the groups. Heart rate, MAP and SpO2 were similar between the groups across time. The onset sensory levels and bromage were significantly (p=0.0001) higher among the patients of Group R compared with R+D. The 2 segment sensory regression (min), sensory regression S2 (hr), motor recovery (hrs), long term mobilization after spinal anesthesia, total amount of vasopressor given and total amount of Atropine given were significantly (p<0.05) lower among the patients of Group R compared with R+D. The percentage of complications was almost low in both the groups. Conclusion: Dexmedetomidine may be more suitable drug in surgeries in which muscle relaxation has greater value in lower abdominal surgeries.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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