The study titled “Assess the Effectiveness of Structured Teaching Program on Knowledge Regarding Self-Care Practice Among 1st Year B.Sc. Nursing Students at Smt. Nagarathnamma College of Nursing, Bengaluru” aimed to evaluate the effectiveness of a structured teaching program on students' knowledge about self-care practices. Introduction: Self-care is crucial in nursing practice, as it helps maintain physical, emotional, and mental well-being. However, nursing students often focus more on patient care, neglecting their own self-care practices. This study aimed to bridge this gap by assessing and improving their knowledge. Methods and Materials: A quantitative approach was adopted, and 45 first-year nursing students were selected through non-probability sampling. Data were collected using a structured questionnaire with 30 items, covering demographic variables and knowledge assessment. Results: The pre-test results showed that 84.44% of students had inadequate knowledge regarding self-care. Following the structured teaching intervention, 57.7% of the students showed adequate knowledge in the post-test. A significant relationship between demographic variables and knowledge improvement was also observed through paired T-tests. Conclusion: The study concluded that the structured teaching program significantly improved the knowledge of self-care practices among nursing students. Incorporating such educational interventions into the nursing curriculum can enhance students' self-care awareness and contribute to better personal well-being and patient care in their professional roles.