EAS Publisher | Colon Tumor Resistance to Chemotherapy: Review of Principle Findings from Recent Studies

Colon Tumor Resistance to Chemotherapy: Review of Principle Findings from Recent Studies

DOI : https://doi.org/10.36349/easjms.2024.v06i10.001

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Colon cancer is among the most prevalent and fatal malignancies and among the most deadly type of tumor in the world. Chemotherapy and surgery are the main choices of treatment for cancer patients. However, Resistance to chemotherapy remains one of the greats challenges mostly for patients with metastatic lesions. This study will provide a comprehensive review of different mechanisms of colon cancer chemotherapy resistance in cancer stem cells including, epithelial-mesenchymal transition (EMT), activation of DNA damage checkpoints, hindrance of the over-expression of antiapoptotic regulatory element, the dormant state of colon cancer, ATP-binding cassette (ABC) transporters, 5-fluorouracil resistance mechanisms in colon cancer, and the presence of reactive oxygen species (ROS) levels will be reviewed. In this paper, the possible mechanisms of chemoresistance in colon cancer are systematically described, which will be beneficial to the further research of chemoresistance in colon cancer.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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