About Us   |   Contact Us   |  
Submission  

Assessment of the Ameliorative Potential of Water-Based Leaf Extracts from Talinum triangulare, Vernonia amygdalina, and Ocimum gratissimum on Liver Damage Caused by Dichlorvos in male wistar Rats

DOI : https://doi.org/10.36349/easjnfs.2024.v06i05.001
PDF
HTML
XML

The increasing human exposure to dichlorvos (DDVP) and its toxicity is a growing public health concern. This work was aimed at studying the therapeutic effect of Vernonia amygdalina, Ocimum gratissimum, Talinum triangulare extracts against DDVP induced hepatotoxicity in rats. Total of 50 male adult rats of average weight 272g were placed in ten groups (n=5) and orally administered normal saline (normal control), 8.0mg/kg body weight DDVP (positive control), 8.0mg/kg body weight DDVP + 200mg/kg and 400mg/kg body weight of the plant extracts and 20 mg/kg body weight and 40 mg/kg bodyweight of vitamin C for 28 days. DDVP significantly (P<0.05) increased Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and Gamma glutamyl transferase (GGT) when compared with normal control. Treatment with aqueous leaf extracts of Vernonia amygdalina, Ocimum gratissimum, Talinum triangulare significantly reversed the distortions in the values of biochemical parameters when compared with positive control. Photomicrographs obtained from histological examination of liver tissues corroborate these findings. Aqueous leaf extracts of Vernonia amygdalina, Ocimum gratissimum, Talinum triangulare may have therapeutic potentials to DDVP induced hepatotoxicity in rats.

TOP EDITORS

OPEN ACCESS JOURNALS

Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

BEST AUTHOR

Of The Month

TRACK YOUR ARTICLE

Enter the Manuscript Reference Number (MRN)
Get Details

Contact us


EAS Publisher (East African Scholars Publisher)
Nairobi, Kenya


Phone : +91-9365665504
Whatsapp : +91-8724002629
Email : easpublisher@gmail.com

About Us


EAS Publisher (East African Scholars Publisher) is an international scholar’s publisher for open access scientific journals in both print and online publishing from Kenya. Its aim is to provide scholars ... Read More Here

*This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2020, All Rights Reserved | SASPR Edu International Pvt. Ltd.

Developed by JM