Hypertension is an important risk factor for the development of numerous cardiovascular diseases. The prevention of hypertension is vital in the reduction of cardiovascular disease mortality and associated morbidities. Numerous studies have focused in the prevalence of hypertension and the prevalence of risk factors for cardiovascular diseases in Nigeria. However, this study investigated the knowledge of women in hypertension, perceived severity of hypertension and barriers towards engaging in hypertension prevention practices so as to establish key areas to focus public health promotion activities. This study was a cross sectional quantitative research carried out to investigate the pyschocognitive determinants of hypertension prevention practices among women residing in Akinyele Local Government Area of Oyo state in Southwest Nigeria. A total of 370 consenting women were recruited into the study using a multi-stage sampling technique and data was collected using the aid of an interviewer-administered questionnaire. Majority of study participants (74.9%) demonstrated fair knowledge of risk factors for hypertension while many participants (65.4%) had good knowledge of prevention practices for hypertension, with an overall mean knowledge score of 12.39±2.37 on a 24-point scale. Many participants (59.2%) had positive perception of severity of hypertension with a mean perception score of 23.80±2.814 on a 27-point scale. The most reported barrier towards engaging in hypertension prevention practices among participants was financial constraint in maintaining healthy eating habits. Furthermore, there is a significant association between participants’ level of education and their knowledge of hypertension. There is also a significant association between barriers towards hypertension prevention such as lack of awareness from media sources, financial constraint and knowledge of hypertension. The knowledge of hypertension among women in Akinyele Local Government Area ........