Introduction: Acute myelomonocytic leukemia with an eosinophilic component (AML4Eo) is a particular and rare hematological entity, representing between 5% and 8% of all acute myeloid leukemias. The aim of our work is to highlight the clinical and cytogenetic epidemiological particularities of this pathology at the Hassan II University Hospital in FES. Patients and Methods: Retrospective descriptive study spread over 14 years (January 2009-January 2023) including all patients diagnosed with LAM4Eo.Myelogram reading as well as immunophenotyping by flow cytometry on Cytomic FC500 were performed at the central hematology laboratory and cytogenetics at the genetics laboratory CHU HASSAN II of FES. Clinical data were collected from patients' medical charts. Results: Thirteen patients were enrolled. The mean age at diagnosis was 20.4 years, with a predominance of males (54%) most patients presented with an altered general condition, signs of cytopenia and a tumor syndrome. All patients presented with profound anemia associated with thrombocytopenia and hyperleukocytosis. Blood smears showed the presence of peripheral blasts in 80% of cases. All medullograms met the morphological criteria established by the FAB (Franco-American-British) classification for the diagnosis of LAM4Eo.Cytochemical staining with myeloperoxidase was performed on all medullograms and was positive in all cases. Immunophenotyping was carried out in 56% of patients, showing the existence of very immature blasts expressing myeloblast and monoblast markers. Four of our patients underwent cytogenetic studies, with no translocation or inversion of chromosome 16. Three patients died immediately after diagnosis. The other patients were put on chemotherapy, two of whom died during treatment. Discussion/Conclusion: LAM4Eo is a rare hematological malignancy with a better prognosis than other myeloid leukemias. Despite the development of cytogenetics and molecular biology techniques, morphological examination ..