A high level of economic growth in a country only sometimes reflects a similar increase in all regions. Disparities in economic growth between regions often occur, even when overall economic growth has increased. This research aims to analyze the influence of economic growth on the level of regional inequality in Papua Province. This research is explanatory research that uses the causality method. The secondary data used in this research is collected by conducting documentation studies at several Papuan government agencies. This research was conducted in Papua Province because it is one of the provinces with a high level of regional inequality in the Republic of Indonesia. The data in this research was obtained using document study techniques. Data analysis techniques are carried out using data collection, data reduction, and data categories. This research shows that economic growth has a negative and significant effect on regional inequality in Papua Province, where increasing production in all economic sectors can create jobs, increase income and reduce the unemployment rate, so regional inequality in Papua Province can be reduced. In the future, the Papua Provincial Government will need to implement strict policies regarding mining activities' environmental and social impacts. The Papua Provincial Government also needs to increase economic diversification by strengthening non-mining sectors to reduce dependence on the mining and quarrying sector.