Hyperlipidemia is implicated in many disease states, including arteriosclerosis, diabetes mellitus, hypertension, obesity and stroke amongst other illnesses. The present study describes the hypolipidemic and testicular cytoarchitecture protective effects of hydromethanol leaf extract of Craterispermum schweinfurthi using male Wistar rats as models. 64 male Wistar rats were acclimatized and subsequently randomly divided into 8 groups of 8 rats each. Diabetes was induced in all rat groups except Groups 1 and 8 using alloxan at a dose of 200mg/kg bw administered intraperitonially. Diabetes was confirmed after 72 hours of alloxan administration if the blood glucose level is ≥ 11.1 mmol/L (200mg/dl) and were daily treated with different concentrations of extract and phytosterol only for 28 days. Expectedly, significantly higher values of total cholesterol, triglyceride, low density lipoprotein, low values of high-density lipoprotein and significant reduction in the population of epithelial germ cells and normal matured spermatozoa in the testes were observed amongst group 2 (Untreated Diabetes) rats administered 200mg/kg bw of alloxan, compared to group 1 (Control) rats (p<0.05). Suggesting a possible hyperlipidemic and harmful testicular effects of alloxan in male Wistar rats. By corollary, extract administration significantly lowered values of total cholesterol, triglyceride, low density lipoprotein, increased values of high-density lipoproteins and reversed the reduction in germ cells and matured spermatozoa population amongst Groups 4 and 5 rats administered 500mg/kg bw and 750mg/kg bw of the extract of Craterispermum schweinfurthi compared to Group 2 (Untreated Diabetes) rats (p<0.05). Suggesting a possible reversal and protective effects of the extract. Craterispermum schweinfurthi extract administration lowered total cholesterol, triglyceride, low density lipoprotein, increased serum high density lipoprotein concentration and promoted germinal epithelial cells ...