Introduction: Dental and oral health problems in the world are still very concerning. Many dental health programs have been carried out. Plaque control is one way to maintain oral hygiene. The research objective was to determine the effectiveness of a dental health program based on plaque control in elementary school-age children. A systemic review of the meta-analysis was designed based on the Preferred Reporting Item for System Review and Metha Analysis). Methods and Material: Data search was conducted on the PubMed and Google Scholar databases. Articles published between 2012-2022 with inclusion criteria: Population (P): Children aged 6-12 years boys and girls. Intervention (I): Dental health education for plaque control programs in schools. Comparison (C): schools without dental health programs. Out came (O): Index plaque. Study Design (S): Experimental Study with Random Control Trial. The keywords used are: Dental Health Education. Exclusion criteria: research without ethical clearance, children with special needs. Screening process: Screening was carried out by 4 (four) researchers. Statistical Analysis used: Analisys data used Revman. Results: In the research results table it can be seen that there is a difference in plaque scores between the pre test and post test. And the P value between the intervention group and the control group found a significant difference. Conclusions: Dental health education programs conducted in schools can reduce plaque scores in children 6-12 years old.