The health of the population is one of the priority sectors of the Malian state authorities. The implementation at the operational level of socio-health activities by health professionals remains a challenge given working conditions and societal realities. This situation in an unfavorable environment exposes these professionals to the development of burnout. Observation: It was a health professional, 48 years old, a civil servant for 10 years in the district, having consulted for insomnia, osteoarticular pain and anorexia. Mood disorders, nervousness, palpitations, physical asthenia persisting for 7 months had been observed. Several consultations and assessments carried out without success. The persistence of the symptoms and the negativity of the assessments made it possible to raise the hypothesis of a professional burnout syndrome. A treatment based on rest over 1 month combined with anxiolytics for 15 days allowed the symptoms to improve. Follow-up for 11 months was unremarkable. Conclusion: The workload, the insufficiency in the organization, the planning of activities and sometimes the failure of the patient to fulfill their duties in our structures are determining factors in the occurrence of burnout among health professionals. Sufficient recruitment of professionals at the operational level, health education and the implementation of an adequate work plan could reduce this risk.