Background: The pancreas becomes inflamed when someone has pancreatitis. When the digestive enzymes are triggered before they are released into the small intestine and start targeting the pancreas, pancreatic injury results. Pancreatitis comes in two different flavours: acute and chronic. Gallstones and alcohol use are two of the many factors that can cause pancreatitis. Pancreatitis can be treated well with medicinal plants. Desmodium gangeticum (DC), a plant of the Fabaceae family, is also known as salpan, salvan, and sarivan in Hindi. The plant is bitter, sweet, thermogenic, nervine tonic, aphrodisiac, carminative, constipating, diuretic, febrifuge, cardiotonic, anticholinestrase action, anti-inflammatory, and expectorant, and it is highly beneficial in treating a variety of medical conditions. Method: In the current work, NF-kβ receptor inhibitors were sought after using a molecular docking approach. The binding was determined by the Auto Dock software utilizing a grid-based docking method. Compounds' 2D structures were constructed using the chem sketch, converted to 3D, and then energetically reduced up to an arms gradient of 0.01. (MMFF). Result: D.gangeticum found to be effective anti-pancreatitis agent and their lead molecules (daidzein and genistein)effectively binds to be target protein NF-kβ receptor with binding energy -5.99 & -5.81 kcalmol-1 for daidzein & genistein respectively. Conclusion: It was discovered through a computationally based docking analysis that both lead compounds exhibit strong NF-KB receptor inhibiting effects. The results demonstrated a promising docking score and lead molecule's pattern of binding to the target protein's active region with strong covalent bonding. The synergistic impact of daidzein and genistein is what gives aqueous extract from D gangeticum its ability to heal pancreatitis.