Background: Ghee and honey has been advocated and used as dressing for infected wounds by Sushruta (600BC). The gratifying results observed with the dressing have prompted this study which aims to establish its efficacy in chronic infected wounds over one year period A standardised ghee and honey dressing was used to treat: chronic post- operative wounds and infected per op wounds, Honey and ghee dressing markedly reduces the foul odour and discharge, significantly improving the quality of life. The study will tell us comparative result of honey and ghee dressing as compared to expensive vacuum dressing and the regular dressing materials. Innumerable Randomised Control Trials (RCTs) reported on honey dressing for infected wounds, there is substantial evidence that ghee and honey dressing has at least comparable results to other modes of treatment. The easy availability and low cost of this treatment makes it significant in developing countries. Specially in rural population, Required permission has been from the HOD of orthopaedics. Material and Methods: Total 20 patients with compound fracture and chronic infected wound, were studied during the period of March 2023 to June 2023 at BVP RMC Loni, Maharashtra. Honey and ghee were taken from a fresh sealed box in 50:50 portion according to size of wound and mixed well then it was applied on the wound directly and covered with gauge and, the dressing was changed is cleaned with sterile normal saline as compared to normal dressing materials ie betadin, povidon iodine ointment, spirit. All Patients data was collected and compiled in Microsoft excel and were statistically analysed using appropriate statistical test using SPSS software. Results: Majority patient were males. Mean duration of wound healing among honey and ghee dressing was 15.3 and of regular dressing was 8.9 days. Conclusion: Honey is one alternative solution that can be used for non-pharmacological therapy. Honey can be used as a topical dressing .........