Background: Congenital deafness is caused by affecting factors that occur during pregnancy and at birth. The prevalence of congenital deafness in the world ranges from 1 to 3 events out of 1000 babies born alive. The level of public knowledge regarding congenital deafness–especially among the parents–is an important factor for management of children with congenital deafness starting from screening to final management. Objective: To describe level of knowledge about congenital deafness in Southern Tatura District. Methods: Descriptive observational study was used. Respondents were from Southern Tatura District, Palu city. The study was conducted in May 2018. Respondents who met the inclusion and exclusion criteria were interviewed using a questionnaire to assess the level of knowledge regarding congenital deafness. Results: Of 98 respondents, most of them were women (69.39%), were in the age group of 18-39 years (79.6%), were self-employed (51.03%) and had graduated from senior high school (53.07%). Among all respondents, we found that only 4.08% had good of knowledge about congenital deafness, 20.4% had moderate, and 7.51% had low knowledge. Conclusion: People living in the South Tatura District, Palu City had low knowledge of congenital deafness.