This study is aimed at empirically investigating the relationship between trade liberalization and economic growth in Nigeria. Real gross domestic product and degree of openness were used as measures of economic growth and trade liberalization respectively. Exchange rate and inflation were used as check variables. The aforementioned variables for the study were sourced from the Central Bank of Nigeria. The Augmented Dickey fuller (ADF) was used to test for data stationarity, while the specified model was estimated using the Fully Modifies Ordinary Least (FMOLs) square method. Findings from the study show that there is positive and statistical significant relationship between degree of openness and real gross domestic product. The aforementioned result indicates that the adoption of liberal trade policies will likely bring about economic growth. However economic growth and development are not the same. Historical and empirical evidence from Nigeria have shown that liberal trade policies have not favoured the country. Nigeria’s productive capacity has been and has remained low and as a result Nigeria consumes more than it produces. In addition, the country has not been able to develop its local productive capacity. Thus, this paper recommends that the government should be tactful in the formulation and implementation of trade policies.