Managing end-stage renal failure poses a significant challenge for healthcare professionals, requiring a comprehensive approach to ensure the best outcomes for patients. The main therapeutic options include hemodialysis, peritoneal dialysis, and kidney transplantation, each with its own advantages and disadvantages. It is crucial to recognize that these methods are not mutually exclusive but rather complementary, and can be used sequentially or in combination according to individual needs. Hemodialysis involves using a machine to filter blood through an artificial kidney and remove waste and excess fluid from the body. This procedure is typically performed in a dialysis center several times a week and can be burdensome for patients due to the need for regular clinic visits. Peritoneal dialysis is another treatment option in which the peritoneum, a membrane inside the abdomen, is used as a semi-permeable membrane to filter blood. This method can be performed at home, offering more flexibility and comfort for patients. However, it requires increased patient commitment and may pose a higher risk of infections. Kidney transplantation is often considered the optimal treatment for end-stage renal failure, offering better quality of life and longer survival compared to dialysis. However, the limited number of donors and strict compatibility criteria make this option inaccessible for many patients. Therefore, it is essential for nephrology centers to offer these three therapeutic options to meet the varied needs of patients. By customizing treatment plans based on individual preferences and providing continuous support, we can improve the management of end-stage renal failure and outcomes for patients and their families. By adopting a collaborative approach, we can better address the growing demand for care for this population.