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Antisynthetase Syndrome Revealed by Glomerular Syndrome

DOI : https://doi.org/10.36349/easms.2021.v04i11.010
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Renal involvement in antisynthetase syndrome, although less frequent than other manifestations such as inflammatory myopathy or interstitial lung disease, is an important complication that can present as acute or chronic renal failure as well as significant proteinuria. The exact mechanisms are not fully understood, but various renal lesions have been described. Diagnosis relies on clinical evaluation, laboratory and imaging tests, as well as detection of autoantibodies, notably anti-Jo 1 antibodies. A multidisciplinary approach involving rheumatologists, nephrologists, and other specialists is necessary for comprehensive evaluation and rapid identification of renal complications. Early intervention and close monitoring are crucial to optimize clinical and renal outcomes in patients with this syndrome. As was the case with our 30-year-old patient managed for glomerular syndrome, with a history of early abortions. She presents with symptoms including muscle weakness, joint pain, Raynaud's phenomenon, cough, and general deterioration. Biological examinations show anemia, inflammation, liver and muscle involvement, as well as proteinuria and hematuria. Anti-Jo1 antibodies are positive, confirming autoimmune reactivity. Radiological examinations reveal pulmonary and muscle involvement, corroborating the clinical picture. Treatment with corticosteroids and immunosuppressants is initiated, leading to significant improvement in the patient's condition. Antisynthetase syndrome, although rare, can affect multiple organ systems, including the kidneys. Its diagnosis relies on multidisciplinary evaluation and detection of specific autoantibodies. Treatment aims to control inflammation and prevent complications. Long-term monitoring is necessary to maintain clinical and biological improvements.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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