The purpose of this study is to examine, either concurrently or partially, the impact of information technology, work discipline knowledge, and abilities on the performance of personnel at Air Force Hospital (RSAU) Dr. Esnawan Antariksa Halim Perdana Kusuma Jakarta. Additionally, the purpose of this study is to determine which of work discipline, knowledge, ability, and information technology have the greatest impact on the performance of personnel at RSAU Dr. Esnawan Antariksa Halim Perdanakusuma Jakarta. The design of the study is explanatory in nature. The research population comprised all forty members of the organization led by the first officer at RSAU, Dr. Esnawan Antariksa Halim Perdana Kusuma Jakarta. Due to the relatively small size of the population, census research was conducted on every member of the first officer staff at RSAU. As the research respondent, Dr. Esnawan Antariksa Halim Perdana Kusuma Jakarta will serve. Hypothesis testing and multiple linear regression are components of the analysis method. The findings of the study indicate that work discipline, knowledge, ability, and information technology have an impact, either simultaneously or partially, on the performance of first officer members at RSAU Dr. Esnawan Antariksa Halim Perdana Kusuma Jakarta. Moreover, this study has established that knowledge predominates over employee performance at RSAU. Kusuma Jakarta's Dr. Esnawan Antariksa Halim Perdana.