Introduction: Severe malaria is a public health problem that causes a real socio-economic burden in developing countries. It is associated with high but avoidable mortality thanks to preventive and curative measures. Methodology: This is a descriptive and cross-sectional study with a prospective survey for the benefit of mothers of children aged 06 to 59 months hospitalized for serious malaria in the pediatric department of the Reference Health Center of Commune I of Bamako from October 2021 to September 2022. Results: In 12 months, 624 children were hospitalized, including 151 children aged 6 to 59 months suffering from severe malaria. The hospital frequency of severe malaria in this age group from 06 to 59 months was 24.2%. The average age of the mothers interviewed was 27.8 years with a range of 15 to 48 years. Mothers were educated in 84.1%, married in 98.7% and working as housewives in 81.5%. The reason for consulting children was fever (91.4%), anorexia (90.1%), prostration (79.5%). Mothers knew about impregnated mosquito nets and smoke coils as means of prevention against malaria at the same frequency of 99.3%, repellent creams 96.7%, and indoor spraying in 92.7%. In practice, they used smoke coils in 64.2%, repellent cream in 44.4% and mosquito nets impregnated with insecticide in 40.4%. Mothers attributed the cause of malaria to mosquito bites in 91.4%; They had readjusted the way sick children were fed by giving more food than usual (29.8%), splitting meals (21.8%) or using active feeding (14.6%). Most children had severe malaria, neurological form or anemic form at the same proportion of 37.1%. The assessment of the nutritional status of children revealed 18.5% acute malnutrition. The children had received conventional and traditional self-medication in 63.58 and 58.94% of cases respectively before admission. In children, a significant relationship was noted between severe anemic malaria and acute malnutrition (Fisher's exact test = 18.41; p = 0.01). ....