EAS Publisher | Allicin Improves Olfactory Response to Rewarding Stimuli Using Buried Reward Test

Allicin Improves Olfactory Response to Rewarding Stimuli Using Buried Reward Test

DOI : https://doi.org/10.36349/easms.2024.v07i02.002

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Garlic, known as Allium sativum, is used in food and medicine. Allicin is one of the main bioactive agents found in garlic. This study investigated the tendency for allicin, a bioactive agent in garlic, to improve olfactory response in male wistar rats exposed to cadmium chloride-induced toxicity. Thirty male wistar rats were sampled in six groups of five rats each. The treatments were; group 1 (control)- water and feed, group 2-CdCl2 (5mg/kg) group 3-allicin(20mg/k), group 4-allicin(40mg/kg), group 5- CdCl2 (5mg/kg) +allicin (20mg/kg), group 6- CdCl2 (5mg/kg) +allicin(40mg/kg). Olfactory response was tested using buried reward test with the result presented as latency (in seconds). Statistical significance was tested at 95% confidence interval (P≤0.05). There was a significant decrease (P≤0.05) in latency and an increase in olfactory response in response to increase in the dose of allicin administered. CdCl2 alone caused a significant increase (P≤0.05) in latency and decrease in olfactory response but when combined with allicin treatment there was a significant improvement in olfactory response. Allicin improves olfactory response dose-dependently using buried reward test.

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