Background: Liver cancer is a major health problem in Egypt. Understanding its epidemiology can help identify high-risk groups and inform prevention strategies. Objective: To investigate regional and occupational variations in liver cancer characteristics and diagnoses in Damietta governorate, Egypt. Methods: An observational study was conducted using data from the Damietta Cancer Institute in 2021. 128 case diagnosed as Liver cancer were analyzed based on age, location, occupation, cancer stage, provisional diagnosis, and sex. Results: Primary liver cancer was more prevalent in younger individuals while metastatic cancer dominated in older age groups. Certain areas exhibited higher primary cancer rates than others. Provisional diagnoses varied by occupation and location. Male patients presented with more advanced stages and distant metastasis compared to females. Conclusions: Geographical and occupational disparities exist in liver cancer profiles. Sex differences were observed in disease presentation. Robust studies are needed to establish causal relationships and explore underlying disease mechanisms. Understanding regional cancer patterns can help prioritize preventive efforts and develop targeted screening programs.