EAS Publisher | Effect of ethanolic leaf extracts of petersianthus macrocarpus on Haematological Parameters and Lipid Profile of Streptozotocin Induced Type 2 Diabetic Wistar Rats

Effect of ethanolic leaf extracts of petersianthus macrocarpus on Haematological Parameters and Lipid Profile of Streptozotocin Induced Type 2 Diabetic Wistar Rats

DOI : https://doi.org/10.36344/ccijmb.2023.v05i04.004

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Background: The most prevalent kind of diabetes that results from insulin resistance is type 2. Hyperglycemia, polyphagia, polyuria, and polydipsia are the traditional trifecta of symptoms associated with this illness. The purpose of this study was to ascertain the impact of petersianthus macrocarpus ethanolic leaf extract on the lipid profile and haematological markers of streptozotocin-induced type 2 diabetic wistar rats. Materials and methods: Five groups of rats were used: non-diabetic, diabetic, untreated, glibenclamide-treated, ethanolic extract-treated, and 100 mg/kg body weight-treated. Results: The body weight of the rats treated with 100 mg/kg body weight increased, while the body weight of the rats treated with 50 mg/kg body weight decreased, according to the results. Conclusion: 100 mg/kg body weight was determined to be the least effective therapeutic dose, indicating the potential of ethanolic leaf extracts.

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