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Diagnosis of Gamma Heavy Chain Disease: About A Case Report

DOI : https://doi.org/10.36344/ccijmb.2023.v05i04.001
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Introduction: Heavy chain disease (HCD) is characterized by the production of a truncated heavy chain monoclonal immunoglobulin lacking the corresponding light chains. The aim is to highlight the difficulties associated with the biological diagnosis of this pathology. Observation: Serum protein electrophoresis showed hypogammaglobulinemia with restricted gammaglobulin heterogeneity and a peak migrating into the beta-2 globulin zone. Immunofixation revealed a monoclonal band in the gamma heavy chain, with no correspondence with the Kappa or Lambda light chains. Conclusion: The observation we have presented reveals that the diagnosis of gamma heavy chain disease is delicate and relies on several techniques.

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Dr. Afroza Begum

Lecturer, Dept. of Pharmacology and Therapeutics, Shaheed Monsur Ali Medical College & Hospital, Uttara, Dhaka-1230, Bangladesh

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