The mesiodistal diameter of the teeth must be considered during orthodontic diagnosis; the implementation of measurement tools has made it possible to classify each patient into parameters that determine their treatment needs. The aim of this study is to analyze the association between the Bolton Index and dentoskeletal parameters in patients who come to receive orthodontic treatment at the University Polyclinic of the Mexicali Faculty of Dentistry of the Autonomous University of Baja California. A cross-sectional analytical observational study was carried out. The sample consisted of 45 initial plaster models that met the inclusion criteria. The models were measured to obtain the Bolton Index. Lateral skull radiographs were plotted to determine skeletal class according to Steiner's cephalometric analysis. The data were collected and tabulated in Microsoft Excel 365. A two-factor analysis of variance was performed with several samples per group to determine the association between the Bolton Index with dentoskeletal parameters and sex. To compare the mesiodistal measurements of the teeth, a test was performed. hypothesis for a two-tailed mean difference where the normal distribution was used in both with a significance level of α=0.05. No statistically significant results were found between the values of the analysis of variance and the normal distribution value with a confidence interval of α=0.05. In conclusion no statistically significant difference was found between the results of the dentoskeletal parameters between men and women that determine an association with Bolton index discrepancies.