Conceptually, Cognitive Behavior Therapy is a pattern of human thought formed from a series of interrelated Stimulus-Cognition-Response processes, in which cognitive processes cause a person to feel and act. Since the CBT technique was carried out at LRKM Mitra Husada, specific measurements have never been carried out to see its effect on changes in the self-esteem of the clients who were given the intervention. This study aims to analyze the effect of cognitive behavioural therapy on the self-esteem of methamphetamine users at LRKM Mitra Husada, Foundation of Mitra Husada, South Sulawesi. This study used the Quasi Experiment method with the research design used being the Pretest-Posttest with Control Group Design, using two groups, namely the intervention group that was given the Cognitive Behavioral Therapy Counseling treatment and the control group that was only given a brochure. The results of this study found that there was an effect of Cognitive Behavioral Therapy (CBT) counselling interventions on the self-esteem of methamphetamine users, where the average pretest result was 1.61 and 2.67 post-test with a significance value of 0.000 (p <0.05 ); There was no effect of giving brochures on the self-esteem of methamphetamine users, where the average pretest result was 1.78 and 1.94 posttest with a significance value of 0.257 (p> 0.05); While the results of the comparative test between the intervention group and the control group found that there was no significant difference in the effect on the control group before and after being given the brochure (p-value 0.257) but found differences in the effect on the intervention group before and after being given CBT counselling (p-value 0.000).