Introduction: High sensitive c-reactive protein (hs-CRP) is an important sensitive inflammatory marker, but not a routine laboratory investigation for diagnosis of hypothyroidism. However, many thyroidal conditions involve inflammation in the present study, the level of hs-CRP and its link with hypothyroidism was assessed. Materials & Methods: A total of 60 males and 50 females aged 20-55 years were assessed for the study. Evaluation of hs-CRP was done on SD biosensor standard F200 fluorescent immunoassayauto analyser in serum was also assayed for FT3 FT4 and TSH by enzyme linked immunosorbent assay (ELISA) technique using Stat-fax-2100. Result: In our study, we have found the values of FT3 in cases as 1.21+0.89 pg/ml lower than control values of 1.92+ 0.66 pg/ml, values of FT4 in cases is 0.60+ 0.53 ng/dl as compared to control group value of 1.40 +0.39 ng/dl, values of TSH as 2.07+ 1.19 miu/l higher than the control group of 0.48+1.67 miu/l. The mean values of hs-CRP for cases as 7.85+0.72 higher than the control group with 3.50+0.54. Conclusion: Our study findings suggest that patients with hypothyroidism also have elevated hs-CRP which can have implication related to cardiovascular disease.