Pain is a term that refers to a spectrum of sensations of varying types and intensities, ranging from unpleasant to intolerable. The struggle to relieve pain began with the advent of mankind. Analgesics can be defined as drugs that reduce the sensation of pain without losing consciousness. Analgesics act in different ways on the peripheral and central nervous systems. They differ from anesthetics in that they reversibly eliminate sensation, acetaminophen [known in the US as acetaminophen, or simply APAP], non-steroidal anti-inflammatory drugs [NSAIDs] such as salicylates, morphine and opioids such as opiates. When choosing an analgesic, the severity and response to other drugs determine drug choice. World Health Organization [WHO] pain ladder. Herbal medicines have less side effects and less harm, so they have a higher market value. The nutritious jujube fruit (Ziziphus jujube Mill.) is a member of the Rhamnaceous family and grows mainly in inland areas of Europe, southern and eastern Asia, Australia and especially northern China. Jujubes have a long history as fruit and medicinal. The main bioactive components are vitamin C, phenols, flavonoids, triterpenoids and polysaccharides. Recent phytochemical studies of jujube fruit have highlighted the following biological effects: B. Anticancer, anti-inflammatory, anti-obesity, immunostimulatory, antioxidant, hepatoprotective and gastrointestinal protective activity in macrophages and inhibition of foam cell formation. Further focus on clinical trials and phytochemical definitions of jujube fruit will be essential for future research efforts. In this study, an attempt was made to evaluate the analgesic potential of Ziziphus jujube hydroalcoholic fruit extract.