Sleep is one of the basic human physiological needs that can restore the body to its physiological functions after daily activities. Lack of sleep quality can significantly impact the body, one of the effects of which is related to chronic low-level inflammation and changes in the competence of the immune system. This research aims to knowing the relationship between sleep quality levels and Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in medical students of Universitas Nusa Cendana. It is an observational analytical study using the cross-sectional method. The number of research samples was determined using a hypothesis test formula against relative risk, with a total sample of 54 people. The population of this study is the class of 2019, 2020, and 2021 using the proportionate stratified random sampling technique, which divides populations into sub-populations in a propositional and random manner. The relationship test used is the ETA test. Based on the results of relationship testing using the ETA test, sleep quality with Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio shows that sleep quality has no significant relationship with Neutrophil Lymphocyte Ratio (p-value = 0,324); however, it has a significant relationship with the Platelet Lymphocyte Ratio (p-value = 0,042). Sleep quality does not have a significant relationship with the Neutrophil Lymphocyte Ratio but has a significant relationship with the Platelet Lymphocyte Ratio. 228 kata.