Baby Blues Syndrome (BBS) is a psychological disorder in postpartum mothers. This can interfere with milk production. The mother cannot provide adequate breast milk to the baby and cannot take care of the baby properly. This study was conducted in two health center in rural and two in urban. This was a comparative descriptive design using with cross sectional approach. The number of respondents was 119 postpartum mothers taken by purposive sampling technique. Data were collected through questionnaires and interviews. The percentage incidence of BBS was 75.6%. From the results of Chi-Squre test, the factors that significantly influence the incidence of BBS include education (p=0,023), type delivery (p=0,025), family economic status (p=0,005), and social support (p=0,039). From the different Mann Whitney Test, it was found that there were differences in factors between rural and urban areas, including education (Sig.2 Tailed=0,029), occupation (Sig. 2 Tailed=0,001), nutritional status (Sig. 2 Tailed=0,001), parity (Sig. 2 Tailed=0,010), type delivery (Sig.2 Tailed=0,000), and family economic status (Sig.2 Tailed=0,000). Mothers with low family economic status and education in rural areas need capacity building through training (cooking and sewing) and education (counseling). Class activities for pregnant women by involving partners or families to increase social support, as well as counseling about the consequences of pregnancy out of wedlock and mental health for pregnant women to promote better physical, mental and social health.