Reproduction is important evolutionary process that is necessary for the maintenance of life. Human fertility depends on a number of endocrine factors, one of which includes the regulation of thyroid hormone. The thyroid's role in neurocognitive and fetal development is of key importance. Any disruption in the regulation of the thyroid gives rise to a thyroid disorder. The underactivity of this gland will lead to a condition known as hypothyroidism. The prevalence of hypothyroidism is way more in females, especially during their reproductive period. Infertility in males is also a key concern nowadays. The prevalence of infertility in males is one of the concerning topics for the couple as a whole. The hormonal assessment serves as a guide for the evaluation of fertility. The metabolic activity of iodine in the regulation of thyroid normal function is very essential. The present narrative review aims to evaluate thyroid hormone physiology, hypothyroidism, the major types of hypothyroidism, its correlation with fertility, and with the patients that are suffering from polycystic ovarian syndrome. This review article will discuss the iodine association with hypothyroidism and its potential role in fertility. It will aim to provide a precise understanding of associated thyroid disorders that are majorly linked with male infertility.