Breast cancer and its treatment interfere significantly with different spheres of a woman’s life and perturb functioning, and can have a deep impact on both short and long-term quality of life (QOL).Aim of the study: To assess the impact of Bio-socio-demographic characteristics on the quality of life of women undergoing surgery as a treatment for breast cancer in Riyadh. Materials and Methods: A descriptive cross sectional design was utilized in this study. The study was conducted at the outpatient waiting area of the Oncology department of King Abdul-Aziz Medical City's. Also, was conducted at Zahra Association for breast cancer awarenesss in Riyadh. A non-probability convenient sampling technique was used in this study to recruit 120 Saudi Breast-Cancer patients undergone surgery as a treatment for breast cancer. Results: The results from the present study has strong correlation with the client’s activity level with the functional scales (C30 and BR23).The study showcased the quality of life with socio-demographic characteristics among the Saudi perspective. Three quarters (75%) of women comes under the of age group has educated, married, enough family income settled with their own houses. The quality of life of women undergoing surgery as a treatment for breast cancer was highly correlated with the impact of Bio-socio-demographic characteristics on this study