The Aedes aegypti mosquito is the main vector of dengue fever in Indonesia. Control using synthetic chemical insecticides has a bad impact. Vegetable insecticides from salam leaf extract are a solution to reduce the negative impact of synthetic chemical insecticides. the aim of this study is To determine the efficacy of salam leaf extracts against the death of the Aedes aegypti mosquito. This research was carried out experimentally with the Post-test design with a control group (Post Test Only Control Group), namely, the experimental group receive treatment or intervention (X) followed by a second measurement or observation (O2), with the study population being all Aedes aegypti mosquitoes which were bred in the Laboratory and Workshop of the Environmental Health Department of the Health Polytechnic of the Ministry of Health of Aceh. The results of the efficacy test of salam leaf ethanol extract by spraying obtained LC 50 = 69.103% and LC 90 = 299.972%, by fogging LC 50 = 43.937% and LC 90 = 311.879%. Salam leaves are very effective, the efficacy of Aedes aegypti mosquito mortality is carried out by spray or fogging at a concentration of 90 LC. It is hoped that the results of this study can be applied in the community for efforts to eradicate Aedes aegypti mosquitoes by using vegetable insecticides that can reduce the effects of synthetic chemicals.