Background: A entire of 10% of Chronic Obstructive pulmonary disease (COPD) are never Smokers because of occupational history positive like biogas and air pollution. And 90% of patients are Smokers. Smoking is main cause of COPD in worldwide. Aim: To determine the role of X-Rays in the Detection of Structural Changes Related to COPD in smokers and nonsmokers. Material and Method: This cross-sectional study was conceded out in Radiological department DHQ Medical institution Gujranwala. The duration of study was 4 months i.e. January 2022 to May 2022. Total no of patients was conduct in Radiology department with COPD are 100. Exclusion criteria included all patients who are not with COPD. Results: Total number of participants are 100 in out of which 10% are non-Smokers and 90% are Smokers. In which we evaluate the structural changes related to COPD. The Result shows hyper- inflated lungs (100%) occupy in smokers and never-smokers. And focal bullae are not occupying in smokers and never-smokers and Flattening of diaphragm are (8%) in non-smokers and (92%) in smokers Increase chest size in never-smokers are (1%) and in smokers are (99%) present. Tubular heart is (63%) in smokers and (37%) in non-smokers. Conclusion: In this prospective study 100 patients of COPD are involved of both genders. In which males are more common than females. The overall study rate of COPD in this study is 10/90 with higher occurrence in males in smokers.