Intussusception is a condition characterized by the penetration of one segment of the intestine into another. It is a medical emergency characterized by bowel obstruction. It can be fatal if left untreated, and occurs most often in children. It is a fairly common pathology in our country with seasonal peaks. The objective of this study is to describe the diagnostic and therapeutic clinical epidemiological aspects of intussusception in infants and children in the pediatric surgery department of Fousseyni Daou hospital. Material and methodology: This is a retrospective study which took place from January 2019 to December 2021 at the Fousseyni Daou hospital in Kayes and included in this study all children operated on for intussusception from 0 to 15 years, through the use of patient records. Results: During the study period, we operated on 975 patients, including 63 occlusions and 27 intussusceptions, i.e. 2.76% of operations and 42.85% of occlusions. The male sex was the most represented 18 cases or 66.66%. There was the notion of abdominal pain in all patients, vomiting in 18 patients and rectal bleeding in 7 patients. At the clinical examination the sausage was found in 18 patients, a standard blood test was carried out in all the patients. Ultrasound was the main radiological examination to confirm intussusception. Treatment was surgical in all patients, with resection. Anastomosis in 6 cases due to late management of these patients. In the immediate postoperative course, we noted two surgical site infections and one eventration. Conclusion: Intussusception is a fairly common pathology in our region, but the evolution of which depends on the promptness of treatment.