Background: Burn in children is immediately and potentially life-threating injury. Providing adequate care for burn in children properly is the most important contribution to the successful management. Aim: The present study aimed to evaluate the effect of nursing intervention program on management of burn in children. Design: A quasi- experimental design was used in the current study. Setting: The study was carried out at Burn Units affiliated to Suez Canal University and Ismalia General Hospitals. Sample: A convenience sample of nurses (35) was working at the previous settings and 20 children were suffering from burn injury during the study period. Tools: A structured interview questionnaire and observational checklists to assess nurses' knowledge and practice regarding management of burn in children pre/post nursing intervention program. Results: revealed that, there was a statistically significant improvement in nurses' knowledge and practices post program intervention compared to pre program intervention regarding management of burn in children. Conclusion: The study concluded that, the nursing intervention program improved positively the studied nurses’ knowledge and practices regarding management of burn in children. Recommendation: The study suggested continuous educational program for nurses to update their knowledge and practice regarding management of burn in children.