Despite the decline in burns incidence and mortality in recent years, its management remains complex. Surface burns usually receive conservative treatment due to their re-epithelizing potential. Regenerative therapies with platelet concentrate are used as physiological reservoirs of growth factors and proteins, capable of accelerating tissue regeneration. A quasi-experimental study was conducted, with two groups of 30 patients to determine the clinical effect of Lysate Platelet on tissue regeneration in patients with deep dermal burns. Differences were identified between the use of conventional treatment with Silver Sulfadiazine and Lysate Platelet, as well as determining the final outcome of both treatments, in the Plastic Surgery and Cosmetology Service, of the General Clinical-Surgical Hospital "Dr. Juan Bruno Zayas Alfonso" of Santiago de Cuba, Cuba in the period from February 2013 to February 2014. Percentages and totals were calculated as a summary measure for qualitative variables for statistical analysis of the data. For quantitative variables, the calculation of the average and the standard deviation was performed. The female sex prevailed at ages 18 to 45, with the lower limbs highlighting as the most affected region, in both treatment groups. The application of lysate platelet favored healing and epithelialization in a shorter time than conventional treatment with silver sulfadiazine, with minimal adverse events, without complications, achieving a better quality of the final scar and excellent satisfaction level perceived by the burnt patient.