Public universities play an important role in economic development in Uganda. As the number of public universities increase, their performance becomes key competitive factor. Enterprise Resource Planning Systems (ERPs) is seen as a solution for improved performance. The purpose of this study was to investigate the effect of Enterprise Resource Planning System capabilities on performance of Uganda universities. Universities in Uganda have been performing poorly because of inadequate infrastructure, poor service delivery, lack of management support and unwarranted information insecurity. The objective of this study was to establish the role of information security, examine the influence of management support, evaluate the effect of information system infrastructure and to determine the relevance of service delivery on performance of universities in Uganda. The study was guided by the contingency theory and the Actor Network Theory. This paper discusses secondary data evidence that prevail on the role of Enterprise Resource Planning System integration in Public Universities in Uganda. A number of journal articles were reviewed. The study found out that management support, information security, service delivery, information system infrastructure has a positive effect on performance of universities. Results depicted that Enterprise Resource Planning System had strong effect on performance of organizations including public universities, though less studied in the Uganda context. Conclusively, the role of Enterprise Resource Planning System on performance of Public Universities in Uganda requires field-based empirical evidence by recent research attention. This could also be utilized to develop a model for assessing performance of organizations by Enterprise Resource Planning System.