Background: Pancreatic calculi are a condition characterised by irreversible destruction and fibrosis of the exocrine parenchyma, leading to exocrine pancreatic insufficiency and progressive endocrine failure leading to diabetes. Tropical calcific pancreatitis, an inflammatory condition of the pancreas, is usually associated with the pancreatic duct stones for which lateral pancreatico jejunostomy provides excellent results with acceptable early morbidity and mortality. Objective: To assess the post-operative complications of pancreatico jejunostomy in patients with pancreatic calculi. Methods: This was a descriptive type of prospective study. A total of 26 patients were included in the study between July 2011 to December 2011 in a BSMMU and other private hospitals of Dhaka who underwent lateral pancreatico jejunostomy for pancreatic calculi. Data were collected using a structured questionnaire and presented in tables by number, percentage, mean±SD, median. Results: This study was conducted to find out the efficacy and safety of lateral pancreatico jejunostomy in cases of pancreatic calculi. Highest proportion of the patients (n=26) are in the age group of 30-40 years (13 out of 26 number of patients. The mean age of the patients is 36.74. More than 64% of the patients were male. Female was found in 35% cases. Revealed that 3.84% of the patients were alcoholic. 96.15% of the patients (25 out of 26 patients) were non alcoholic. 30.76% (8 patients out of 26) is associated with gallstone disease.69.23% (18 patients out of 26) is not associated with gallstone disease. Upper abdominal pain was present in 100% patients. Steatorrhoea was present in 15.38% of the patients (4 patients out of 26).Jaundice predominated in 3.85% of the patients (1 patient out of 26). Shows that 34.61% of the patients (9 patients out of 26) developed post-operative morbidity, death occurred in 3.85% (1 patient out of 26). In our study 11.54% of the patients (3 patients out of 26) ............