Introduction This study was the first at the level of the obstetrics gynecology department of the Reference Health Center (CSRef) of Kalaban-coro Kati Mali. The objective was to determine the profile of the pathogenic germs identified and their proportion in case of imbalance of the vaginal flora in the genesis of lower genital infections in women at the level of our service. Methods: This was a descriptive study of the cross-sectional survey type which took place in the gynecology department of the Reference Health Center (CSRef) in the municipality of Kalaban – coro circle of Kati Koulikoro Mali. The study extended over a period of 12 months from February 2015 to January 2016 and involved patients seen in outpatient gynecology at our Center. The size of our sample consisted of 90 patients who agreed to participate in our study. The data was collected through a previously established survey form. Word processing was processed on World 2007 software and data entry and analysis were performed on SPSS 23.0 fr software. The statistical test used was the Chi2 considered significant when P<0.05. Results: The frequency of genital infections was 10.01%. The most represented age group was 20 to 35 years old with 61.1%. The main germs identified were respectively: Candida albicans, Escherichia coli, Klebsiella and Gram-negative Bacilli with 16.7%, 15.7%, 13.4% and 11.1% respectively. Conclusion: At the end of this study, we found that the most frequent germs of lower genital infections were mainly represented by: Candida albicans, Escherichia coli, Klebsiella and Gram-negative bacilli.